FRCR Oncology

Welcome to the FRCR Oncology Study Hub.

This platform is designed to help Clinical Oncology trainees prepare for the FRCR Part 1 examination with clear, high-yield explanations of cancer biology, radiobiology, pharmacology and physics.

Cancer Biology

Cell cycle regulation (cyclins, CDKs, checkpoints)

DNA damage and repair mechanisms (BER, NER, MMR, HR)

Oncogenes vs tumour suppressor genes (p53, RB)

Apoptosis and cell death pathways

Growth factors and signalling pathways (EGFR, RAS, PI3K)

Mechanisms of metastasis

Cancer immunology

Radiobiology

DNA damage from ionising radiation

Linear quadratic model (α/β ratio)

Cell survival curves

Fractionation principles

5 Rs of radiobiology (Repair, Reassortment, Repopulation, Reoxygenation, Radiosensitivity)

Oxygen effect and hypoxia

Normal tissue tolerance

Pharmacology

Cytotoxic chemotherapy classes

Platinum agents (Cisplatin, Carboplatin)

Targeted therapies

Immunotherapy

Hormonal therapy

Physics

Radiation units (Gray, Sievert)

Types of radiation (photons, electrons, protons)

Interaction of radiation with matter

Dose calculation and measurement

Linear accelerators (LINAC)

Imaging principles (CT, MRI basics)

Treatment planning concepts

Statistics

Study design (RCTs, cohort, case-control)

Bias and confounding

Sensitivity, specificity, PPV, NPV

Survival analysis (Kaplan-Meier, hazard ratio)

p-values and confidence intervals

Basic statistical tests

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